My only gripe with an acquisition would be the dilution of Ionis’s ASO therapies in the milieu of chemical drugs which have an incredibly high clinical trial failure rate (greater than 90%!).Potential Risks for Ionis There are a few potential headwinds to consider:1) Ionis’s primary income stream comes from Spinraza, which has recently caused the stock to trade lower due to the slow ramp in Spinraza sales. However, as more insurers provide coverage and administration sites are expanded, the majority of SMA patients should be on therapy.2) In the coming years, Spinraza could face competition from AAV based gene therapy from AveXis (NASDAQ:AVXS). While AveXis’s results were definitely strong, the company will almost certainly have issues filling a placebo controlled trial with Spinraza on the market.
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